Research

Our lab studies two main orthopaedic tissues—bone and cartilage.   Specifically, we are interested in the effects of mechanical loading on these tissues.  Loads can affect the tissues in a variety of ways, including deformation and damage, which are then transduced into changes in cellular signaling.

The primary focus of the lab is to examine:

  • how loading affects orthopaedic tissues, and
  • how disease, age, and drug treatments influence the mechanical properties and composition of these tissues.

We use a variety of techniques to study these topics including:

  • 3 and 4 point bending
  • Quantitative backscattered electron microscopy
  • Atomic force microscopy (with in situ tensile testing)
  • Finite element analysis
  • Surface force apparatus
  • Compression testing
  • Indentation and penetration testing
  • Confocal imaging

We collaborate with

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